Publications
2023
Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice.
Matthew D Campbell, Ashton T Samuelson, Ying Ann Chiao, Mariya T Sweetwyne, Warren C Ladiges, Peter S Rabinovitch, David J Marcinek.
Chiao YA^, Zhang H, Sweetwyne M, Whitson J, Ting YS, Basisty N, Pino L, Quarles E, Thi Nguyen N-H, Campbell MD, Zhang T, Gaffrey MJ, Merrihew G, Wang L, Yue Y, Duan D, Granzier H, Szeto HH, Qian W-J, Marcinek D, MacCoss MJ and Rabinovitch PS^ (2020) Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice. Elife. 2020 Jul 10;9:e55513. (^ corresponding authors)
Quarles E, Basisty N, Chiao YA, Merrihew G, Gu H, Sweetwyne MT, Fredrickson J, Nguyen NH, Razumova M, Kooiker K, Moussavi-Harami F, Regnier M, Quarles C, MacCoss M, Rabinovitch PS. Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment. Aging Cell. 2020 Feb;19(2):e13086. PMID: 31823466
2019
Dai DF, Liu Y, Basisty N, Karunadharma P, Dastidar SG, Chiao YA, Chen T, Beyer RP, Chin MT, Maccoss M, La Spada AR, Rabinovitch PS (2019) Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure. Geroscience 41: 847-860. PMCID: PMC6925086
2018
DeLeon-Pennell KY, Iyer RP, Ma Y, Yabluchanskiy A, Zamilpa R, Chiao YA, Cannon PL, Kaplan A, Cates CA, Flynn ER, Halade GV, de Castro Brás LE, Lindsey ML. The Mouse Heart Attack Research Tool 1.0 database. Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H522-H530. PMID: 29775405 PMCID: PMC6172643
2017
Dai DF, Chiao YA, Martin GM, Marcinek DJ, Basisty N, Quarles EK, Rabinovitch PS. Mitochondrial-Targeted Catalase: Extended Longevity and the Roles in Various Disease Models. Prog Mol Biol Transl Sci. 2017;146:203-241. PMID: 28253986
Sweetwyne MT, Pippin JW, Eng DG, Hudkins KL, Chiao YA, Campbell MD, Marcinek DJ, Alpers CE, Szeto HH, Rabinovitch PS, Shankland SJ. The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney Int. 2017 May;91(5):1126-1145. PMID: 28063595 PMCID: PMC5392164
2016
Lee CF, Chavez JD, Garcia-Menendez L, Choi Y, Roe ND, Chiao YA, Edgar JS, Goo YA, Goodlett DR, Bruce JE, Tian R. Normalization of NAD+ Redox Balance as a Therapy for Heart Failure. Circulation. 2016 Sep 20;134(12):883-94. PMID: 27489254 PMCID: PMC5193133
Richardson A, Fischer KE, Speakman JR, de Cabo R, Mitchell SJ, Peterson CA, Rabinovitch P, Chiao YA, Taffet G, Miller RA, Rentería RC, Bower J, Ingram DK, Ladiges WC, Ikeno Y, Sierra F, Austad SN. Measures of Healthspan as Indices of Aging in Mice-A Recommendation. J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):427-30. PMID: 26297941 PMCID: PMC4834833
Chiao YA, Kolwicz SC, Basisty N, Gagnidze A, Zhang J, Gu H, Djukovic D, Beyer RP, Raftery D, MacCoss MJ, Tian R, Rabinovitch PS. Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts. Aging (Albany NY). 2016 Feb;8(2):314-27. PMID: 26872208 PMCID: PMC4789585
Padmanabhan Iyer R, Chiao YA, Flynn ER, Hakala K, Cates CA, Weintraub ST, de Castro Brás LE. Matrix metalloproteinase-9-dependent mechanisms of reduced contractility and increased stiffness in the aging heart. Proteomics Clin Appl. 2016 Jan;10(1):92-107. PMID: 26415707 PMCID:PMC4922304
2015
Chiao YA and Rabinovitch PS. The Aging Heart. Cold Spring Harb Perspect Med. 2015 Sep 1;5(9):a025148.
Karunadharma PP*, Basisty N*, Chiao YA*, Dai D-F, Drake R, Levy N, Koh WJ, Emond MJ, Kruse S, Marcinek D, MacCoss MJ, Rabinovitch PS. Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages and treatments. FASEB J. 2015 Aug;29(8):3582-92. *Authors have equal contributions. PMID: 25977255 PMCID: PMC4511201
Karunadharma PP, Basisty N, Dai DF, Chiao YA, Quarles EK, Hsieh EJ, Crispin D, Bielas JH, Ericson NG, Beyer RP, MacKay VL, MacCoss MJ, Rabinovitch PS. Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects. Aging Cell. 2015 Aug;14(4):547-57. PMID: 25807975 PMCID: PMC4531069
Ma Y*, Chiao YA*, Clark R, Flynn ER, Yabluchanskiy A, Ghasemi O, Zouein F, Lindsey ML, Jin YF. Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence. Cardiovasc Res. 2015 Jun 1;106(3):421-31. *Authors have equal contributions. PMID: 25883218 PMCID: PMC4498140
2014
Dai DF*, Chiao YA*, Marcinek DJ, Szeto HH, Rabinovitch PS. Mitochondrial oxidative stress in aging and healthspan. Longev Healthspan. 2014 May 1;3:6. *Authors have equal contributions. PMID: 24860647 PMCID: PMC4013820
Yabluchanskiy A, Ma Y, Chiao YA, Lopez EF, Voorhees AP, Toba H, Hall ME, Han HC, Lindsey ML, Jin YF. Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2014 May 15;306(10):H1398-407. PMID: 24658018 PMCID: PMC4024719
Dai D-F*, Karunadharma PP*, Chiao YA*, Basisty N*, Crispin D, Hsieh EJ, Chen T, Gu H, Djukovic D, Raftery D, Beyer RP, MacCoss MJ, Rabinovitch PS. Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart. Aging Cell. 2014 Jun;13(3):529-39. *Authors have equal contributions PMID: 24612461 PMCID: PMC4040127
Grimes KM, Voorhees A, Chiao YA, Han HC, Lindsey ML, Buffenstein R. Cardiac function of the naked mole-rat: ecophysiological responses to working underground. Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H730-7. PMID: 24363308 PMCID: PMC3949069
2013
Zamilpa R, Zhang J, Chiao YA, de Castro Brás LE, Halade GV, Ma Y, Hacker SO, Lindsey ML. Cardiac wound healing post-myocardial infarction: a novel method to target extracellular matrix remodeling in the left ventricle. Methods Mol Biol. 2013;1037:313-24. PMID: 24029944 PMCID: PMC3970183
Chiao YA. MicroRNA-34a: a new piece in the cardiac aging puzzle. Circ Cardiovasc Genet. 2013 Aug;6(4):437-8. No abstract available. PMID: 23963163
de Castro Brás LE, Ramirez TA, Deleon KY, Chiao YA, Ma Y, Dai Q, Halade GV, Hakala K, Weintraub ST, Lindsey ML. Texas 3-Step Decellularization Protocol: Looking at the Cardiac Extracellular Matrix. J Proteomics. 2013 Jun 28;86:43-52. PMID: 23681174 PMCID: PMC3879953
2012
Yang T, Chiao YA, Wang Y, Voorhees A, Han HC, Lindsey ML, Jin YF. Mathematical modeling of left ventricular dimensional changes in mice during aging. BMC Syst Biol. 2012;6 Suppl 3:S10. PMID: 23281647 PMCID: PMC3524011
Chiao YA, Jin Y, Zamilpa R, Dai Q, Ramirez TA, Zhang J, and Lindsey ML. Matrix Metalloproteinase-9 Deletion Attenuates Myocardial Fibrosis and Diastolic Dysfunction in Ageing Mice. Cardiovasc Res. 2012 Dec 1;96(3):444-55. PMID: 22918978 PMCID: PMC3500048
Zamilpa R, Ibarra J, de Castro Brás LE, Ramirez TA, Nguyen N, Halade GV, Zhang J, Dai Q, Dayah T, Chiao YA, Lowell W, Ahuja SS, D’Armiento J, Jin YF, Lindsey ML. Transgenic overexpression of matrix metalloproteinase-9 in macrophages attenuates the inflammatory response and improves left ventricular function post-myocardial infarction. J Mol Cell Cardiol. 2012 Nov;53(5):599-608. PMID: 22884843 PMCID: PMC3472138
Ma Y, Chiao YA, Zhang J, Manicone AM, Jin YF, Lindsey ML. Matrix metalloproteinase-28 deletion amplifies inflammatory and extracellular matrix responses to cardiac aging. Microsc Microanal. 2012 Feb;18(1):81-90. PMID: 22153350 PMCID: PMC3972008
2011
Chiao YA, Dai Q, Zhang J, Lin J, Lopez EF, Ahuja SS, Chou YM, Lindsey ML, Jin YF. Multi-analyte profiling reveals matrix metalloproteinase-9 and monocyte chemotactic protein-1 as plasma biomarkers of cardiac aging. Circ Cardiovasc Genet. 2011 Aug 1;4(4):455-62. PMID: 21685172 PMCID: PMC3158732
2010
Chiao YA, Jin YF, Lindsey ML. Tipping the extracellular matrix balance during heart failure progression: do we always go right? Cardiology. 2010;116(2):130-2. No abstract available. PMID: 20606425 PMCID: PMC2924236
Bansal A, Dai Q, Chiao YA, Hakala KW, Zhang JQ, Weintraub ST, Lindsey ML. Proteomic analysis reveals late exercise effects on cardiac remodeling following myocardial infarction. J Proteomics. 2010 Sep 10;73(10):2041-9. PMID: 20601275 PMCID: PMC2939257
Zamilpa R, Lopez EF, Chiao YA, Dai Q, Escobar GP, Hakala K, Weintraub ST, Lindsey ML. Proteomic analysis identifies in vivo candidate matrix metalloproteinase-9 substrates in the left ventricle post-myocardial infarction. Proteomics. 2010 Jun;10(11):2214-23. PMID: 20354994 PMCID: PMC3017347
Chiao YA, Zamilpa R, Lopez EF, Dai Q, Escobar GP, Hakala K, Weintraub ST, Lindsey ML. In vivo matrix metalloproteinase-7 substrates identified in the left ventricle post-myocardial infarction using proteomics. J Proteome Res. 2010 May 7;9(5):2649-57. PMID: 20232908 PMCID: PMC2866015